A New Study Links Benadryl to Mental Health Problems / Dementia

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A New Study Links Benadryl to Mental Health Problems / Dementia


People take Benadryl for different reasons — to combat allergies or help them fall asleep, for example — but new research suggests that long-term use of the drug may be linked to serious mental health conditions.

A 2016 study published in JAMA Neurology found that the active ingredient in Benadryl, diphenhydramine, appears to impair cognitive functioning and increase the risk of dementia for individuals who take the drug in high doses or as a long-term treatment option. According to CNN, the study was the first to identify physical changes in the brains of those who use so-called anticholinergic drugs, which are found in over the counter medicines like “Benadryl, Demerol, Dimetapp, Dramamine, Paxil, Unisom and VESIcare.”


“These findings might give us clues to the biological basis for the cognitive problems associated with anticholinergic drugs, but additional studies are needed if we are to truly understand the mechanisms involved,” Dr. Shannon Risacher, one of the study’s co-authors, said in a press release.


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