Anti-inflammatories May Help Ease Depression

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Anti-inflammatories May Help Ease Depression


Nonsteroidal anti-inflammatory drugs (NSAIDs) may help ease depressive symptoms, new research suggests.


Results of a meta-analysis show that the adjunctive use of NSAIDs was associated with improved antidepressant treatment response without an increased risk for adverse effects. In particular, add-on treatment with celecoxib (Celebrex, GD Searle LLC) improved antidepressant effects, remission, and response.


“Our analysis suggests that anti-inflammatory treatment, in particular celecoxib, decreases depressive symptoms without increased risks of adverse effects,” the authors, led by Ole Kohler, MD, of Aarhus University Hospital, Risskov, Denmark, write.

The study was published online October 15 in JAMA Psychiatry.

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