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Beta-Blockers May Raise Mortality in People With Diabetes

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Beta-Blockers May Raise Mortality in People With Diabetes


Use of beta-blockers may be associated with an increased mortality risk in patients with diabetes, particularly among those who have coronary heart disease (CHD), new research suggests.
The findings, from prospective cohort data from the US National Health and Nutrition Examination Survey 1999–2010, were published in the April issue of Mayo Clinic Proceedings by Tetsuro Tsujimoto, MD, PhD, of the Department of Diabetes, Endocrinology, and Metabolism, Center Hospital, Tokyo, Japan, and colleagues.
Among nearly 3000 participants with diabetes, all-cause mortality over 5 to 6 years was significantly higher in those taking beta-blockers than those who were not, with an even more pronounced effect among those with CHD.
In contrast, among nearly 15,000 participants without diabetes who had CHD, all-cause mortality was significantly reduced among those who took beta-blockers versus those who didn’t.  
Beta-adrenergic receptor blockers have been shown to improve survival in patients following myocardial infarction (MI), and in those with congestive heart failure (CHF) because of left ventricular systolic dysfunction.
But beyond that, Tsujimoto and colleagues note, “Beta-blockers have never been found to improve survival in all other patients with stable CHD in the absence of [MI] or CHF without systolic dysfunction. Moreover, the efficacy of beta-blockers in diabetic patients with CHD/CHF remains unknown.”
Tsujimoto and colleagues conclude, “Use of beta-blockers may be associated with an increased risk of mortality for patients with diabetes and among the subset who have CHD. Further studies are needed to assess whether beta-blockers are effective in reducing mortality and coronary events in diabetic patients receiving optimal medical treatment.”
Mayo Clin Proc. 2018;93:409-418. Abstract, Editorial

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Heavy kids who lose the weight in childhood can avoid extra diabetes risk

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Heavy kids who lose the weight in childhood can avoid extra diabetes risk

Although being overweight as a child increases the risk of type 2 diabetes in adulthood, a new study shows that the extra risk disappears if that excess weight is lost by age 13 and kept off in early adulthood.

“Until our study came along, it was known that weight reduction in adulthood could reduce the risk of type 2 diabetes,” coauthor Dr. Jennifer Baker told Reuters Health in a telephone interview. “Ours is the first and largest to show if we do this before puberty – and this is a great time for intervention and prevention because children are in school – you can reduce future risks of this disease.”

But the study of more than 62,500 Danish men, detailed in The New England Journal of Medicine, didn’t test whether efforts to get children to lose weight lowers the risk. It simply used registry data to track weights at ages seven, 13 and in early adulthood to look for correlations to diet-dependent diabetes by age 30 to 60.

What they found was that more time spent having a normal weight generally provided more protection.

More than 23 percent of children worldwide are regarded as overweight or obese.

Being overweight at age seven, 13 and in early adulthood made it four times more likely that the person would develop diabetes.

Adding extra pounds by the time puberty arrives and keeping them on as an adult posed a 3.87-fold greater risk.

“Since overweight during puberty appears to be a particularly important factor involved in increasing the risk of type 2 diabetes in middle and late adulthood, normalization of BMI (body-mass index) before these ages may reduce this risk,” the researchers said.

BMI is a ratio of height to weight. A free online calculator is available here: bit.ly/2tXeEf4.

People in the study who didn’t become overweight until they became adults, and were at a normal weight at ages seven and 13, faced a risk that was 3.24 times greater.

Among children who became overweight, only the seven-year-olds who lost it by age 13 didn’t have an increased risk.

Youngsters who were overweight at age seven and 13 but lost the extra weight by early adulthood were still 51 percent more likely to develop type 2 diabetes when they grew up.

“We see this as encouraging, that there is hope for the future if we can help these children normalize their weight through exercise and lifestyle changes, not just diet,” said Baker. “The goal isn’t weight loss, but weight normalization, because they’re still growing.”

The team found no link between intelligence or educational levels and diabetes.

SOURCE: bit.ly/2Gst0KV The New England Journal of Medicine, online April 4, 2018.

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Grilled Meats, Fish Linked to Hypertension

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Grilled Meats, Fish Linked to Hypertension

A high consumption of meat, poultry, or fish grilled, broiled, or cooked at a high temperature is associated with an increased risk for hypertension, independent of the overall amount consumed, and the risk is also increased with higher intake of well-done meat.
“Among individuals who consume red meat, chicken, or fish regularly, our findings imply that avoiding the use of open-flame and/or high-temperature cooking methods, including grilling/barbecuing, broiling, and roasting, may help reduce hypertension risk,” lead author, Gang Liu, PhD, a postdoctoral research fellow in the Department of Nutrition at the Harvard T.H. Chan School of Public Health in Boston, Massachusetts, told theheart.org | Medscape Cardiology.

Hazardous Chemicals

Grilled food is known to cause the formation of chemicals that can be carcinogenic, and Liu noted that while previous research has not shown a risk for hypertension, key mechanisms could explain the increased risk.
“Although the exact reason remains unclear, accumulating evidence has suggested that cooking meats at high temperature can produce several hazardous chemicals, including heterocyclic aromatic amines (HAAs), polycyclic aromatic hydrocarbons (PAHs), and advanced glycation end products (AGEs), which could induce oxidative stress, inflammation, and insulin resistance in animal studies,” Liu said.
“These pathophysiological pathways may also lead to an elevated risk of developing hypertension,” he said.
While the authors underscore that the study doesn’t prove cause and effect, Liu said the findings nevertheless spotlight the potential role of grilled or high-temperature cooking in hypertension.
“Our findings suggest that it may help reduce the risk of high blood pressure if you don’t eat these foods cooked well done and avoid the use of open-flame and/or high-temperature cooking methods, including grilling/barbequing and broiling,” Liu said.



American Heart Association EPI | Lifestyle Scientific Sessions: Epidemiology and Prevention | Lifestyle and Cardiometabolic Health 2018.

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Magnesium: The Fact That Can Kill You

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Magnesium: The Fact That Can Kill You

Ronald Grisanti D.C., D.A.B.C.O., D.A.C.B.N., M.S.

Magnesium can be the one thing that can save someone from an instantaneous deadly heart attack. In fact, it could be the answer for an out of control arrhythmia.
Going back as far as 1990 the Journal of the American Medical Association reported that well over half of hospitalized patients were seriously low in magnesium.
Unfortunately, the reporting of these findings were not by the physicians in the hospital but by respected scientists and researchers doing the study.
The sad truth of it all is over 90% of these physicians never ordered any magnesium test.
Those having the lowest levels of magnesium had the highest risk of dying from a heart attack or a deadly arrhythmia while in the hospital.
Government studies prove the average diet provides less than a third of the magnesium you need in a day and its deficiency is a major cause of sudden death with no other obvious medical problems.
Even diabetics are at risk of developing deadly complications due to a deficiency in magnesium. A respected medical study reported that 77% of diabetics were deficient in magnesium.
Here is a fact that everyone MUST remember.
Do not accept that your magnesium levels are normal if your doctor has ordered the inferior “serum” magnesium test.
Here is the kicker!
If your serum magnesium levels are shown to be high your doctor may assume everything is fine and lead you to believe there is nothing to worry about.
This is 100% incorrect and could be deadly!
Why you may ask?
Because as the magnesium inside the heart cell goes down, the body tries to compensate. So the serum magnesium actually goes up!
start quoteThe serum magnesium can actually be high or even too high, when at that same time your RBC magnesium (inside the heart cells) is so low you could have an instantaneous fatal heart attack.end quote

This is an extremely important fact for you to know: the serum magnesium (called simply “magnesium” when you see your lab test) can actually be high or even too high, when at that same time your RBC magnesium (inside the heart cells) is so low you could have an instantaneous fatal heart attack.
Here is something even more frightening.
When your “intracellular” magnesium levels are low and you suffer a heart attack or an arrhythmia not even the easy access of a defibrillator or paddles can activate the heart back to life.
So the point is quite clear… never never never buy into “everything is just fine” if your doctor has ordered the worthless serum magnesium.
Unfortunately, the serum magnesium gives the unknowledgeable physician a sense of security when in fact theyare clueless to the great harm they may be instilling on their patients.
The result of this lack of knowledge could be the patient dies or has a life threatening arrhythmia all because the wrong magnesium blood test was ordered.
If you want to be certain your levels of magnesium are well within the normal range, insist that your doctor orders the most accurate magnesium test and that is the red blood cell (RBC) essential mineral test. The RBC test can be ordered from www.gdx.net or www.doctorsdata.com

Magnesium: The Fact That Can Kill You



References:

  • Sales CH, et al, Magnesium and diabetes mellitus: their relations, Clin Nutr 25; 4:554-62, 2006
  • Sales CH, et al, Influence of magnesium status and magnesium intake on the blood glucose control, in patients with type II diabetes, Clin Nutr, 2011
  • Nielsen FH, et al., Dietary magnesium deficiency induces heart rhythm changes, impairs glucose tolerance and increases serum cholesterol in postmenopausal women, J Am Coll Nutr 26; 2:121-32, 2007
  • Whang R, et al, Frequency of hypomagnesemia and hypermagnesemia, requested versus routine, J Am Med Assoc, 2634:3063-4, 1990

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New UCSD flu discovery could block illness entirely

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New UCSD flu discovery could block illness entirely

Bradley J. Fikes, The San Diego Union-Tribune on 
Scientists led by a UC San Diego chemist reported progress recently in researching a universal flu drug, effective regardless of the strain.

Seth Cohen, a UCSD professor and co-founder of San Diego’s Forge Therapeutics, said the drug inhibits a critical viral enzyme by jamming molecular machinery common to all strains. It could reduce the flu’s severity or perhaps block it completely.
The drug blocks an enzyme containing the metal manganese. Such metalloenzymes form the basis of Forge’s technology, which is currently directed toward developing antibiotics, not antivirals.
“This enzyme is a component that allows the virus to steal the cellular machinery, so that the virus can reproduce using the human cells,” Cohen said. The drug interrupts this process by binding to the manganese ions.
While the results were only observed in lab testing of the viral enzyme, called RNA polymerase, further development in animal testing and eventually humans appears feasible, Cohen said.
UCSD retains the rights to the technology, so Forge or another company would need to license it to bring it to the market.
The results were presented at the 255th National Meeting & Exposition of the American Chemical Society in New Orleans. The drug is a modified version of another compound Forge developed.
The original compound bound to one of two manganese ions in the enzyme. The new version binds to both, making it much more effective, Cohen said.
Next, the effectiveness of the enzyme inhibitor needs to be tested against the entire virus, not just the enzyme. If the virus cannot mutate to bypass the drug, it should be effective therapeutically.
Another enzyme-inhibiting drug, baloxavir marboxil, is already on the market in Japan under the brand name Xofluza. It acts like Tamiflu, but can be taken once a day, compared to twice a day for Tamiflu.
Tamiflu works by a different mechanism, inhibiting a viral surface protein. So Xofluza and other RNA polymerase inhibitors represent a new approach to flu antivirals.
Cohen said the new compound appears to be more effective than Xofluza, although this must be established in human testing. That testing could take a couple of years to start if all goes well, he said.
The current flu season has been one of the nastier on record. In San Diego County alone, more than 300 people have died so far. At the same time last year, 68 deaths had been reported.
(c)2018 The San Diego Union-Tribune
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A Healthy Look Into The World Of Vitamins (Infographic) 2018

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A Healthy Look Into The World Of Vitamins (Infographic) 2018

Proper dieting and food supplements are essential when it comes to people’s overall well being. In fact, if your body were a machine, the vitamins you take would make sure it’s a well-oiled one. You can take your vitamins either from natural sources or by using food supplementation products. Since knowing what’s good for you is the first step to leading a healthy and carefree life, this infographic will show you which are the most important vitamins, what’s the minimum daily intake, and where you can find the best nutrients in nature.
Now that we’ve highlighted the importance of living healthy, let’s debunk the theory that a healthy lifestyle is expensive. Although certain vitamins can’t be found in abundance in nature – hence the need for food supplements – there’s an abundance of companies providing high-quality nutrition products. Those of you who think high-in-nutrients snacks are out of your price range, feel free to check out any of the NatureBox coupon codes and offers. You’ll see that proper dieting doesn’t have to be a luxury; although receiving snacks at your doorstep does feel luxe.
While vitamins don’t produce energy as carbohydrates, fat, or proteins do; they make sure that our body remains fully functional. Leading a healthy life and keeping your vitamin levels in-tact is of utmost importance for staying in good shape. If you, however, fail to take enough vitamins, carbohydrates, or proteins from natural sources, you can always rely on MyProtein or other supplement retailers. Finally, check out the infographic below and see where you can find the vitamins you need and what could happen if you don’t.

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Smoking tied to higher risk of hearing loss

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Smoking tied to higher risk of hearing loss

(Reuters Health) – Smokers may be more likely to develop hearing loss than nonsmokers, and the risk increases with each additional cigarette people smoke on a typical day, a Japanese study suggests.


Researchers examined data on almost 50,000 Japanese workers, ages 20 to 64, who didn’t have hearing loss. After a maximum follow-up of eight years, more than 5,100 people developed hearing loss.


Compared to nonsmokers, people who currently smoked were 60 percent more likely to develop high-frequency hearing loss that makes it hard to understand speech in noisy environments. Current smokers were also 20 percent more likely to develop low frequency hearing loss that makes difficult to detect deep voices.


“The more one smokes, the higher the risk of hearing loss,” said lead study author Huanhuan Hu of the Department of Epidemiology and Prevention at the National Center for Global Health and Medicine in Tokyo.


“Quitting smoking virtually eliminates the excess risk of hearing loss, even among quitters with short duration of cessation,” Hu said by email. “Because the risk of hearing loss increases with the number of cigarettes smoked per day, if quitting is impossible people should still smoke as little as possible.”


At the start of the study, participants were typically in their 40s, and about 19,000 of them were current smokers. About 9,800 were former smokers and 21,000 had never smoked.


Current smokers were more likely to be overweight or obese, have chronic health problems like high blood pressure and diabetes, and work in jobs with higher levels of occupational noise.


Each year during the study, participants had comprehensive hearing tests.


Compared to nonsmokers, people who currently smoked up to 10 cigarettes a day were 40 percent more likely to develop high frequency hearing loss and 10 percent more likely to develop low frequency hearing loss, the study found.


When smokers went through 11 to 20 cigarettes a day, they were 60 percent more likely to develop high frequency hearing loss and 20 percent more likely to develop low frequency hearing loss.


With more than 20 cigarettes a day, people were 70 percent more likely to develop high frequency hearing loss and 40 percent more likely to develop low frequency hearing loss.


While the study wasn’t a controlled experiment designed to prove whether or how smoking might cause hearing loss, it’s possible that nicotine exposure may damage the ears, Hu said.


Other limitations of the study include the reliance on participants to accurately report on their smoking habits, researchers note in Nicotine and Tobacco Research. The study also lacked on occupational noise exposure for all of the people in the study.


Still, the findings add to a growing body of evidence suggesting that smoking can contribute to hearing loss, said Dr. Matteo Pezzoli, a hearing specialist at San Lazzaro Hospital in Alba, Italy, who wasn’t involved in the study.


“The study showed clearly that there is a direct link between the number of cigarettes smoked and the damage suffered,” Pezzoli said by email.


“To maintain the hearing we have when we’re young, in addition to quitting smoking it is also important to lead a healthier lifestyle and increase sporting activities,” Pezzoli added. “It is also very important to protect your ears from prolonged exposure to loud noise.”


SOURCE: bit.ly/2pdBqyo Nicotine and Tobacco Research, online March 14, 2018.

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DASH Diet Linked to Lower Risk for Depression

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DASH Diet Linked to Lower Risk for Depression

A diet previously shown to reduce hypertension and stroke risk may also help ward off depression, new research suggests.
Participants who most closely adhered to the low-sodium Dietary Approaches to Stop Hypertension (DASH) diet were 11% less likely to become depressed over time than those least adherent to the diet, the study found.
The results suggest that the DASH diet may have the “dual benefit” of protecting against cardiovascular disease and helping to boost mood, lead author, Laurel J. Cherian, MD, assistant professor, vascular neurology, Rush University Medical Center, Chicago, Illinois, told Medscape Medical News.
“I think that’s a valuable tool for us as neurologists.”
Late life-depression is a “major issue,” not only for patients aging normally but also for those with cognitive issues and those who have had a stroke, said Cherian. “For me, as a stroke doctor, I know that post-stroke depression is a major issue that is undertreated, and contributes to morbidity.”
The study will be presented April 23 at the upcoming American Academy of Neurology (AAN) 2018 Annual Meeting in Los Angeles, California.
American Academy of Neurology (AAN) 2018 Annual Meeting. Abstract 3569 (P2.179). To be presented April 23, 2018.

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Wine tied to healthier arteries for some diabetics

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Wine tied to healthier arteries for some diabetics




Some diabetics with plaque buildup in their arteries might have less debris in these blood vessels after adding wine to their diets, a recent study suggests.


For the study, researchers examined data on 224 people with type 2 diabetes who normally didn’t drink alcohol, but were randomly assigned to follow a Mediterranean diet and drink approximately one glass of red wine, white wine or water for daily. Among the subset of 174 people with ultrasound images of their arteries, 45 percent had detectable plaque at the start of the study.


Two years later, researchers didn’t see any significant increase in plaque for any of the participants with ultrasounds, regardless of whether they drank wine or water.


However, among the people who started out with the most plaque in their arteries, there was a small but statistically meaningful reduction in these deposits by the end of the study, researchers report in the European Journal of Clinical Nutrition.


“Among patients with well-controlled diabetes and a low risk for alcohol abuse, initiating moderate alcohol consumption in the context of a healthy diet is apparently safe and may modestly reduce cardiometabolic risk,” said lead study author Rachel Golan, a public health researcher at Ben-Gurion University of the Negev in Beer Sheva, Israel.


“Our study is not a call for all patients with type 2 diabetes to start drinking,” Golan said by email.


Cardio-metabolic risk factors can increase the chances of having diabetes, heart disease or a stroke. In addition to plaque in the arteries, other risk factors include high blood pressure, elevated blood sugar, high cholesterol, smoking and having poor diet and exercise habits.


Alcohol may help, but it also isn’t risk free, noted Dr. Gregory Marcus, a researcher at the University of California, San Francisco, who wasn’t involved in the study. It can increase the risk of heart rhythm problems, which can cause stroke, Marcus said by email.


Even though alcohol might help reduce the risk of cardiovascular disease in some circumstances, there isn’t enough evidence yet to suggest that people who avoid alcohol should start drinking, Marcus said.


“I would certainly recommend against starting to drink alcohol in the hopes of obtaining beneficial health effects among anyone that currently abstains,” Marcus said. “And among those who drink, these sorts of positive results should never be used to consume more alcohol, particularly beyond drinking in moderation.”

SOURCE: go.nature.com/2HHX7PB European Journal of Clinical Nutrition, online January 29, 2018.

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Young men’s drinking tied to later liver disease risk

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Young men’s drinking tied to later liver disease risk


Men who drink alcohol in late adolescence are more likely to develop severe liver disease decades later than young people who don’t drink at all, a Swedish study suggests.


Researchers examined data on alcohol consumption for 43,296 men entering military service in 1969 and 1970 when they were 18 to 20 years old. After an average follow-up of almost 38 years, a total of 383 men were diagnosed with severe liver disease, including 208 who died.


Each daily gram of alcohol men typically consumed in their youth was associated with a 2 percent increase in the risk of severe liver disease, even after researchers accounted for other independent risk factors for liver damage like obesity, smoking and cardiovascular disease.


The risk was more pronounced among heavier drinkers. Young men who typically averaged 31 to 40 grams of alcohol (equivalent to roughly 3 to 5 ounces of spirits) daily had twice the risk of liver disease as abstainers, while youth who drank 51 to 60 grams daily had more than quadruple the risk of liver disease.


In the U.S., one standard drink contains 14 grams (0.6 oz) of alcohol, which is typically the amount in one 12-ounce beer, a 5-ounce glass of wine and 1.5 ounces of spirits, according to the National Institute on Alcohol Abuse and Alcoholism.


The exact amount of alcohol needed to inflict liver damage is unclear and can be influenced by other factors like what people eat, what type of alcohol they consume and how often they binge drink, researchers note in the Journal of Hepatology. But some previous research points to an increased risk of liver disease when men drink more than 30 grams of alcohol daily or when women consume more than 20 grams a day.


Overall, the young men in the current study drank an average of almost 9 grams daily. While roughly 6 percent claimed not to drink at all, almost 5 percent consumed more than 60 grams daily.


During almost four decades of follow up, 2,661 men were diagnosed with alcohol abuse, and roughly one in 10 of these men went on to develop severe liver disease.



“It’s quite likely that many of those who reported drinking regularly during their late teens went on to continue or escalate that habit throughout their adult life,” Grucza said by email. “In an ideal world, parents would both try to delay alcohol initiation until the late teens or early twenties and also try teach their kids to drink moderately and responsibly.”




SOURCES: bit.ly/2sIFpYQ and bit.ly/2EJMgTc Journal of Hepatology, online January 22, 2018.

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