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Celiac Disease Linked to Almost Doubled Risk of CAD
Compared with the general population, individuals with celiac disease were almost twice as likely to have CAD, according to a large retrospective study presented here today at the American College of Cardiology (ACC) 2014 Scientific Sessions [1]. Even patients younger than aged 65 years were at higher risk.
Celiac disease—a chronic inflammatory condition of the digestive system that can damage the small intestine—was also linked with a 1.4-fold greater risk of stroke.
The study highlights a specific patient population that might be at higher risk of CAD, even in the absence of traditional CV risk factors, said coinvestigator Dr Rama Dilip Gajulapalli(Cleveland Clinic, OH). “Primary-care physicians, gastroenterologists, and [other] healthcare practitioners need to be mindful of their celiac patients; they have to be on the watch for probable cardiac diseases,” he said during a press briefing.
The possible mechanism for the heightened risk may be related to chronic inflammation. “People with celiac disease have some persistent low-grade inflammation in the gut that can spill immune mediators into the bloodstream, which can then accelerate the process of atherosclerosis and, in turn, CAD,” Gajulapalli explained in a statement. “Our findings reinforce the idea that chronic inflammation, whether it’s from an infection or a disease, can have an adverse role in CAD and heart health in general.”
“These data remind us that other inflammatory states like lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease have also been linked to CAD, so perhaps we can add celiac disease to this list,” echoed moderator Dr Jeffrey Kuvin (Tufts Medical Center, Boston, MA).
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