Cutting Just 300 Calories a Day Benefits The Heart, Even in the Healthy
Reducing daily food intake by the equivalent of just a couple of cookies, or around 300 calories, over 2 years leads not only to improvements in body composition but a range of cardiometabolic risk factors that could result in reductions in the incidence of cardiovascular disease, the results of an innovative study suggest.
The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) trial is a phase 2 study involving more than 200 normal to slightly overweight but otherwise healthy individuals up to aged50 years.
They were assigned to a personalized calorie restriction diet combined with individual and group counseling sessions aimed at reducing energy intake by 25%, or an ad libitum control group, who continued with their normal diet.
William E. Kraus, MD, Duke University School of Medicine, Durham, North Carolina, and colleagues report that individuals in the intervention group actually achieved an average reduction in energy intake of almost 12% over 2 years, with an average weight loss of 7.5 kg (approximately 16.5 lbs).
This was associated with significant improvements in lipid levels over baseline, as well as better insulin sensitivity, metabolic syndrome scores, and C-reactive protein levels. The research, published online July 11 in Lancet Diabetes & Endocrinology, showed that, in comparison, there were no significant changes in individuals assigned to their normal diet.