Diabetes and Adiposity Cause 1 in 20 Cancers Worldwide
Nearly 6% of cancers, equating to almost 800,000 cases globally, were attributable to type 2 diabetes and overweight/obesity in 2012, new data show, with adiposity being responsible for almost twice as many cases as diabetes.
The study represents the first to estimate the worldwide cancer burden due to diabetes alone and also to diabetes and high body mass index (BMI) combined, say Jonathan Pearson-Stuttard, BMBCh, Imperial College London, United Kingdom, and colleagues in their paper published online November 28 in Lancet Diabetes & Endocrinology.
Approximately one in four liver and esophageal adenocarcinomas and 38.4% of endometrial cancers worldwide in 2012 were estimated to be attributable to diabetes and high BMI.
Cancers caused by diabetes and being overweight or obese were almost twice as common in women as men (496,700 cases vs 295,900 in men).
In men, liver cancer was the commonest cancer caused by diabetes and high BMI, accounting for 126,700 cases, or 42.8% of all cancers caused by these two factors. Colorectal cancer was the second commonest, accounting for 63,200 new cancer cases, or 21.4%.
In women, breast cancer was the commonest cancer caused by diabetes and high BMI, accounting for 147,400 cases, or 29.7% of such cancers. Endometrial cancer was the second commonest, accounting for 121,700 new cancer cases, or 24.5%.
A recent survey by ASCO found that fewer than one in three people realize obesity is a risk factor for cancer, even though it is the second leading preventable cause of the disease.
Lancet Diabetes Endocrinol. Published online November 28, 2017. Article, Editorial