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Diabetes Drugs Tied to Less Amyloid, Slowed Cognitive Decline in Alzheimer’s
Among patients with cognitive impairment, those with diabetes who took dipeptidyl peptidase-4 (DPP-4) inhibitors had less amyloid beta (Aβ) in the brain compared to the patients with diabetes who did not take these medications and to the patients without diabetes, new research shows. DPP-4 inhibitors are a class of oral hypoglycemic agents.
The analysis also showed that the patients with diabetes who took a DPP-4 inhibitor experienced slower cognitive decline over time compared to those who did not take the drug.
“This study provides evidence that diabetic patients with comorbid Alzheimer’s disease can benefit from a DPP-4i,” study investigator Seong Ho Jeong, MD, clinical professor at Inje University College of Medicine and Sanggye Paik Hospital, Seoul, South Korea, told Medscape Medical News.
The results highlight the need to study these drugs in patients with Alzheimer’s disease (AD) who do not have diabetes, said Jeong.
The study was published online August 11 in Neurology.
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This study only SUGGESTS this relationship. It does not mean that diabetes drugs show direct causality and will lower amyloid proteins and lower Alzheimer’s Disease itself. The study is not a randomized controlled clinical trial, it’s impossible to draw firm conclusions about this type of drug and Alzheimer’s.
via Blogger https://bit.ly/3yQbknC
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