Gout Linked to Increased Vascular Disease Risk

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Gout Linked to Increased Vascular Disease Risk

Patients with gout, particularly women, have increased risk for vascular disease, according to findings of a study published online August 27 in the Annals of Rheumatic Diseases.

Hyperuricaemia, the biochemical precursor to gout, has been linked with an increased incidence of, and mortality from, both [coronary heart disease (CHD)] and stroke,” writes Lorna E. Clarson, MBChB, from the Research Institute for Primary Care & Health Sciences at Keele University in the United Kingdom, and colleagues.

 “Although gout is traditionally thought of as an intermittent inflammatory condition, recent ultrasound studies have identified persistent subclinical inflammation in the intercritical period between acute attacks. It has been hypothesised that the combination of persistent inflammation and hyperuricaemia may potentiate or synergise CHD development.”

Dr. Clarson and colleagues examined the association of gout with incident CHD, cerebrovascular disease (CVD), and peripheral vascular disease (PVD) in a large cohort of primary care patients with gout.

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