Gut Microbe ‘Cross Talk’ in Early Life and Type 1 Diabetes

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Gut Microbe ‘Cross Talk’ in Early Life and Type 1 Diabetes

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Compromised interaction between gut microbes in infants and toddlers who go on to develop type 1 diabetes might play a role in the pathogenesis of anti-islet–cell autoimmunity and consequent development of the disease, new results from the largest study of its kind indicate.

The work was published online March 7 in Diabetes.

The researchers, from the Institute of Diabetes Research, Helmholtz Zentrum, Munich, Germany, also found that the gut microbiome at an early age was strongly influenced by factors such as delivery mode and fundamental changes in nutrition.

Our findings suggest that alterations in the establishment of the early gut microbiome, in particular in the interaction between bacteria, might lead to unfavorable conditions and a compromised ‘cross talk’ between the gut microbiome and the host immune system,” said David Endesfelder, PhD.

“In combination with environmental triggers occurring later in life, these conditions might eventually cause the development of autoimmunity.”

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