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Higher Intake of Trans Fats Harms Brain Function
Higher intake of trans fat, commonly used in processed foods to improve taste, texture, and shelf life, has been linked to worse memory function in men in their prime earning years.
Beatrice A. Golomb, MD, PhD, of the University of California, San Diego, and colleagues analyzed data on 694 men who completed a dietary survey and a word recall test. On average, men aged 45 years and younger recalled 86 words.
However, each gram per day of dietary trans fatty acid intake was associated with an estimated 0.76 fewer words recalled (P= . vs
Adjustment for systolic blood pressure, waist circumference, and body mass index, but not lipid or glycemic variables, attenuated the relationship, “consistent with mediation by factors involving, relating to, or concurrently influencing, these factors,” the investigators write.
These observational data in humans are “buttressed by experimental data in animals [in that] rats fed trans fats have impaired memory acquisition,” Dr Golomb told Medscape Medical News.
“In terms of brain function more broadly, our work has previously shown an association between trans fat consumption and worse mood and more aggressive behaviors. Thus, trans fats show adverse associations with two of the other key pillars of brain function, mood and behavior,” she said.
The study was published online June 17 in PLoS One
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