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Intermittent Fasting Plus Lower-Calorie Diet May Be Best
Overweight women who ate a lower-calorie diet and fasted 3 days a week lost more weight and had better cardiometabolic markers than women who only reduced their calorie intake, or only fasted, or did neither in a small, 8-week randomized trial.
“Obese women who followed a diet in which they ate 70% of their required energy intake and fasted intermittently lost the most weight,” said lead author Amy T. Hutchison, post-doctoral researcher, Adelaide Medical School, University of Adelaide, Australia, in a statement from her university.
“Other women in the study,” she noted, “who either fasted intermittently without reducing their food intake, who reduced their food intake but did not fast, or did not restrict their diet at all, were not as successful in losing weight.”
The new findings from the Effects of Periodic Fasting Versus Daily Energy Restriction on Metabolic Health (PREFER) study were published in the January issue of Obesity
“Intermittent fasting was more effective than diet restriction for reducing body weight and improving metabolic health when prescribed with a similar energy deficit, but it did not differentially impact insulin sensitivity assessed by hyperinsulinemic-euglycemic clamp,” say Hutchison and colleagues.
And when intermittent fasting was prescribed without energy restriction, there were transient elevations in diabetes risk markers “and no overall improvements in metabolic parameters compared with other groups, despite minor weight loss,” they observe.
“This study demonstrates that intermittent fasting approaches using repeated 24-hour fasts improve metabolic health when in energy deficit but not when in energy balance,” they conclude.
The research was funded by a National Health and Medical Research Council project grant. The authors have reported no relevant financial relationships.
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