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Lack of Vitamin D Linked to CVD Biomarkers, Inflammation
Older, healthy individuals who were deficient in 25-hydroxy vitamin D (vitamin D) tended to have higher levels of biomarkers linked with CVD and inflammatory conditions such as multiple sclerosis and rheumatoid arthritis, in an observational study
More specifically, individuals who had a vitamin-D deficiency had significantly higher levels of interleukin-6 (IL-6) and C-reactive protein (CRP) and higher IL-6:IL-10 and CRP:IL-10 ratios, compared with their peers who were not deficient.
This is the first study to demonstrate that vitamin-D status is linked with markers of inflammation in a population of independently living, older adults and the first to investigate the link between vitamin D and inflammatory ratios, which may be more reliable measures of inflammation, Dr Mary Ward(University of Ulster, Coleraine, United Kingdom) told heartwire in an email.
“The results suggest that older adults with a deficiency in vitamin D may be at risk of having a more proinflammatory immune profile. . . Which in itself may be a risk factor for [acute or] chronic disease development, [including] CVD, osteoporosis, and cognitive dysfunction,” she said. “However, further research needs to be undertaken in order to confirm these findings.”
The study was published online February 25, 2014 in the Journal of Clinical Endocrinology and Metabolism.
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