Living in Very Cold Climate and Increases Cancer Risk

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Living in Very Cold Climate and Increases Cancer Risk


Populations living in extremely cold or high-altitude environments have genes that boost survival but that also predispose individuals to cancer later in life, especially lung, breast, and colorectal cancer, according to researchers.
Analysis of data from the GLOBOCAN-2012 survey of worldwide cancer incidence shows that evolutionary adaptation to environments of extreme or prolonged cold produces genetic variants that interfere with tumor suppression and increase vulnerability to almost all cancers.

“This is the first study that provides evidence that high cancer risk may be a result of evolutionary adaptation in certain environmental conditions,” note Konstantinos Voskarides, PhD, of the University of Cyprus Medical School in Nicosia, and colleagues.
Notably, the findings support a “long-standing hypothesis for cancer” known as antagonistic pleiotropy, the authors say in their report, published online December 5 in Molecular Biology and Evolution.

Mol Biol Evol. Published online December 5, 2017.

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