Low Vitamin D Tied to Testosterone Decrease in Healthy Men

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Low Vitamin D Tied to Testosterone Decrease in Healthy Men

Low levels of vitamin D are significantly and independently associated with low levels of testosterone in otherwise healthy middle-aged men, according to a study presented at the American Urological Association 2015 Annual Meeting in New Orleans.


In this new analysis of data from of the World Trade Center CHEST program, blood samples from 824 men were analyzed for various parameters, such as 25-hydroxyvitamin D and total testosterone. Hypovitaminosis D was defined as a 25-hydroxyvitamin D level below 30.0 ng/L.


The Framingham 10-year cardiovascular risk score was used as a proxy for general cardiovascular risk.


Level of 25-hydroxyvitamin D were insufficient in 68% of the samples. And only about 11% of participants with insufficient levels took vitamin D supplements, “which is pretty low,” said lead investigator Mary Ann McLaughlin, MD, from the Mount Sinai Hospital in New York City.


Total testosterone was higher in men with normal levels of 25-hydroxyvitamin D than in men with lower levels (341.7 vs 319.6 ng/L; P = .012).


Even after adjustment for the Framingham 10-year risk score, “subjects with hypovitaminosis D still had significantly lower total testosterone than those with normal total testosterone (P = .019),” Dr McLaughlin and her colleagues report.


American Urological Association (AUA) 2015 Annual Meeting: Abstract MP51-04. Presented May 17, 2015.

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