Nine Risk Factors May Explain Two Thirds of AD Cases

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Nine Risk Factors May Explain Two Thirds of AD Cases


Nine potentially modifiable risk factors may explain two thirds of Alzheimer’s disease (AD) cases globally, according to a comprehensive meta-analysis of published studies.


Risk factors include obesity, carotid artery narrowing, low educational achievement, hyperhomocysteine, depression, hypertension, frailty, current smoking, and type 2 diabetes (diabetes only in Asian populations).


According to the analysis, the population attributable risk (PAR) for each of the factors individually ranged from 0.175% to 24.5%, while a model combining all nine factors yielded a PAR of 66%.

Jin-Tai Yu, MD, PhD, from the Memory and Aging Center, Department of Neurology, University of California San Francisco, and colleagues report their findings online August 20 in the Journal of Neurology, Neurosurgery and Psychiatry.

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