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PRP Injections Are NOT Better than Placebo for Ankle Osteoarthritis
Platelet-rich plasma (PRP) injections did not significantly improve pain or function when compared with placebo injections in patients with ankle osteoarthritis (OA), a new study has found.
“Previous evidence for PRP injections in ankle osteoarthritis was limited to 4 small case series with methodological flaws,” write Liam D. A. Paget, MD, of the University of Amsterdam, the Netherlands, and co-authors. The study was published online today in the Journal of the American Medical Association.
To assess the value of PRP injections as a treatment for ankle OA, the researchers launched a double-blind, randomized clinical trial of Dutch patients with notable ankle pain and tibiotalar joint space narrowing. From six sites in the Netherlands, 100 patients (45% women, mean age 56 years) were split into two groups: one that received two intra-articular injections of PRP 6 weeks apart (n = 48) and one that received two injections of saline placebo (n = 52).
JAMA. Published online October 26, 2021. Abstract
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