‘Remarkable’ Findings From Diabetes Prevention Trial
Middle-aged patients with impaired glucose tolerance (IGT) who can delay their progression to type 2 diabetes by 6 years — usually by making lifestyle changes — have a lower risk of diabetes-related complications when they are in their 70s, Asian researchers report.
Guangwei Li, MD, China-Japan Friendship Hospital, Beijing, China, and team presented the 30-year findings from the Da Qing Diabetes Prevention Outcome Study as a poster and during an oral session here at the American Diabetes Association (ADA) 2019 Scientific Sessions, and Li outlined the results to assembled journalists during a press briefing.
Compared with participants who developed type 2 diabetes within 6 years of study enrollment, those who did not do so were 30% less likely to develop cardiovascular disease (CVD) (defined as stroke, myocardial infarction, or heart failure) and 58% less likely to develop microvascular complications (defined as neuropathy, nephropathy, or severe retinopathy) during the next 24 years.
The findings show that adults with IGT “have a very bright future, if you can delay diabetes for only 6 years,” Li told Medscape Medical News.
Clinicians should advise normal-weight patients with IGT to restrict sugar and alcohol, he stressed, and encourage overweight or obese patients to lose weight. Indeed, the study intervention meant that 32% of patients returned to normal glucose tolerance at the end of the trial.
ADA 2019 Scientific Sessions. Presented June 8 (abstract 1468-P) and June 10 (abstract 153-OR).