Smoking Makes MS Worse!

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Smoking Makes MS Worse!


Inflammation could be a key mechanism behind the well-accepted adverse associations between cigarette smoking and multiple sclerosis (MS), a new review of the evidence suggests.
Cigarette smoking triggers lung irritation, which in turn causes inflammation that can progress to the autoimmunity driving central nervous system (CNS) demyelination in MS, researchers note, particularly among those who are genetically susceptible.
They also found that e-cigarettes could contribute to MS disease activity, progression, and MRI changes, although more data are needed.
The “take home message” is that “smoking worsens MS disease severity and progression,” Tanuja Chitnis, MD, of the Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, told Medscape Medical News.
Because smoking is a modifiable risk factor, “having MS patients stop smoking can improve outcomes,” Chitnis added.
The study was published online December 16 in JAMA Neurology.

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