SSRI May Negatively Affect Male Fertility

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SSRI May Negatively Affect Male Fertility

The selective serotonin reuptake inhibitor (SSRI) sertraline (Zoloft, Pfizer Inc) may have a negative impact on some semen parameters, a finding that may have implications for male fertility, new research suggests.

A randomized, single-blind study in men being treated with the drug for premature ejaculation (PE) showed that the drug significantly reduced sperm concentration and percentage of normal morphology and significantly increased percentage of sperm deoxyribonucleic acid (DNA) fragmentation compared with behavioral therapy (BT).

“Our study revealed detrimental effects of sertraline on some semen parameters. It should particularly be considered in patients who are trying to conceive,” the authors, led by Zahra Sepehrmanesh, MD, Kashan University of Medical Sciences in Iran, write.
The study was published online February 12 in Urology.

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