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Stress Does Increase the Risk for Ulcers

Psychological stress increased risk for peptic ulcer regardless of Helicobacter pylori infection status or use of nonsteroidal anti-inflammatory drugs, according to data from a prospective study of a population-based cohort in Denmark.

“Peptic ulcer has always been considered a classic example of psychosomatic interactions, but the literature finding ulcer to be caused by life stress is plagued with methodological limitations:  inadequately documented diagnoses, cross-sectional methodology, and/or lack of information about major known ulcer risk factors,” Susan Levenstein, MD, from the Aventino Medical Group in Rome, Italy, told Healio Gastroenterology.

“Doubt therefore remains as to whether the detected association might be due to confounding, diagnostic bias, or the stressful effect of ulcer symptoms.”

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