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Study: Diabetes Drug May Help Manage Weight
A diabetes drug called semaglutide helped people who are overweight or obese lose an average of 15% of their body weight over 16 months, according to a new study published Wednesday in The New England Journal of Medicine.
The once-a-week shot works by increasing the production of insulin and appears to also suppress appetite. It’s under review by the FDA as a chronic weight management drug. If approved, it would be the fifth prescription weight loss drug on the U.S. market.
“This is by far the most effective intervention we have seen for weight management when you compare it to many of the currently existing drugs,” Robert Kushner, MD, one of the study authors and an internal medicine doctor at Northwestern Medicine, said in a statement.
The average baseline weight was 230 pounds, and the average body mass index was 38. Overall, people in the study group lost about 15% of their body weight in 68 weeks, as compared with a 2.4% loss in the placebo group. On average, people who took the drug lost about 33 pounds, and those in the placebo group lost 5 pounds.
About 70% of the study participants reached a loss of 10% or more of their body weight, which is considered clinically relevant, Kushner said. Other chronic weight management drugs on the market have helped people to lose 6% to 11% of their body weight, so semaglutide could be nearly twice as effective, he said.
But they noted several limitations. For instance, most of the participants were white, which doesn’t reflect the U.S. population. In addition, the trial didn’t investigate the long-term efficacy of sustained weight loss. Current drugs on the market often don’t perform well in the real world, and some have been pulled due to side effects.
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