Type 2 Diabetes Linked to Tau Tangles in Brain (Dementia?)

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Type 2 Diabetes Linked to Tau Tangles in Brain (Dementia?)

Older people with type 2 diabetes have an elevated level of tau protein in their cerebrospinal fluid (CSF) whether they have normal cognition, mild cognitive impairment (MCI), or dementia, a new study has shown.

As higher levels of tau in the CSF reflect greater accumulation of tau tangles in the brain, the results suggest that type 2 diabetes may contribute to this build-up of tangles, said author Velandai Srikanth, PhD, associate professor, medicine, and head of the Stroke and Aging Research Group, Monash University, Melbourne, Australia.

The finding might help explain why patients with type 2 diabetes have almost a two-fold increased risk for dementia and Alzheimer disease (AD), he said. “Tau pathology is an avenue that needs to be pursued as a potential mechanism.”

Their results were published online September 2 in Neurology.

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