http://goo.gl/U4Stxs
Sometimes I like to speak directly to my readers about topics that are becoming increasingly apparent to me as I read more on issues of science, the body, annd how they relate to illness and disease.
It is becoming increasingly evident that peripheral organ-centered inflammatory diseases, including chronic inflammatory liver diseases, are associated with changes in central neural transmission that result in alterations in behavior. I am speaking of sickness behaviors, such as fatigue, cognitive dysfunction, mood disorders, and sleep disturbances.
While such behaviors have a significant impact on quality of life, the changes within the brain and the communication pathways between the liver and the brain that give rise to changes in central neural activity are not fully understood.
Primary immune deficiency diseases (PIDs) are a mixed and large group of inherited diseases characterized by many genetic immune defects, causing susceptibility to recurrent infections. They have a vast array of manifestations some of which involve the digestive and liver-gall bladder systems. These complications can be the consequence of five different factors, namely, infection, autoimmune process, unregulated inflammation, malignancies and complications of therapeutic intervention
Understanding how the liver communicates with the brain in the setting of chronic inflammatory liver diseases will help delineate novel therapeutic targets that can reduce the burden of symptoms in patients with liver disease.
via Blogger http://chiropractic-lane.blogspot.com/2013/08/gastrointestinal-hepatic-immune-axis.html
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