High-Fat Diet Linked to Anxiety, Depression

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High-Fat Diet Linked to Anxiety, Depression

Consuming a high-fat diet may cause brain changes that lead to anxiety and depression, and although switching to a healthy diet reverses metabolic changes, mood problems persist, preliminary research suggests.
Results of the mouse study showed that a high-fat diet is linked to type 2 diabetes and anxiety and depression and that such a diet blunts the beneficial effect of antidepressants.
The research was led by Bruno P. Guiard, PhD, Centre National de la Recherche Scientifique, Centre de Recherches sur la Cognition Animale, Toulouse, France, and Xavier Fioramonti, Center des Sciences du Goût et de l’Alimentation, Université de Bourgogne Franche-Comté, Dijon, France.
“There is a controversy regarding whether type-2 diabetes and major depression are causally linked,” the investigators write. “Our present study provides clear-cut evidence, using an original approach based on the z-score method, that both pathologies are well correlated, notably when type-2 diabetes is induced by a prolonged high-fat diet.
“Considering the prevalence of type-2 diabetes and major depression, and their consequences on morbidity, mortality and quality of life, the optimization of current antidepressant treatment is highly required,” they add.
The study was published online October 16 in the British Journal of Pharmacology.

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