Midlife High Blood Pressure Affects BP-Cognition Link in Old Age
Knowledge of blood pressure in midlife is crucial to understanding the link between blood pressure and cognitive impairment in old age, a new study suggests.
The study — part of the Age, Gene/Environment Susceptibility (AGES)-Reykjavik study, which has been following a population from Iceland since 1967 — found that the relationship between blood pressure and brain changes consistent with cognitive impairment in late life depended on whether the individual had a history of hypertension in midlife.
In those without a history of midlife hypertension, higher late-life systolic and diastolic blood pressure was associated with an increased risk for white matter lesions and cerebral microbleeds. In contrast, in participants with a history of midlife hypertension, lower late-life diastolic pressure was associated with smaller total brain and gray matter volumes and lower memory scores.
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