Botulin Injections May Relieve Major Depression
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Just a single treatment with onabotulinumtoxinA (OBA), a botulinum toxin that is approved by the US Food and Drug Administration (FDA) for cosmetic purposes to treat frown lines, appears to ease depressive symptoms, new research suggests.
Results from the randomized, double-blind, placebo-controlled trial showed that OBA resulted in “significant and sustained” improvement in the depressive symptoms of patients with moderate to severe unipolar depression.
“This research is groundbreaking because it offers those who suffer from depression and their doctors an entirely new approach to treating the condition, one that doesn’t conflict with any other treatments,” study investigator Norman E. Rosenthal, MD, clinical professor of psychiatry, Georgetown Medical School, Washington, DC, said in a statement.
“The fact that this works on patients who were on 2 SSRIs [selective serotonin reuptake inhibitors] and on patients who were on no medication tells me that the mechanism of action is different from that of the SSRIs,” he added.
However, he stressed that using OBA to treat depression is currently experimental and that OBA is not FDA approved for that purpose.
The study was published in the May issue of the Journal of Psychiatric Research.
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