Lithium Linked to Poor Renal and Endocrine Function

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Lithium Linked to Poor Renal and Endocrine Function

Lithium, the cornerstone treatment for bipolar disorder, is associated with a decline in renal function, hypothyroidism, and hypercalcemia, new research suggests.


“Lithium is a widely used and highly effective treatment for mood disorders, but causes poorly characterized adverse effects in kidney and endocrine systems,” write investigators, led by Brian Shine, MD, from John Radcliffe Hospital, Oxford, United Kingdom. “We aimed to analyze laboratory information system data to determine the incidence of renal, thyroid, and parathyroid dysfunction associated with lithium use.”


The findings were published online May 20 in the Lancet.

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