2 Skin Disorders May Signal Underlying Endocrine Disorders

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2 Skin Disorders May Signal Underlying Endocrine Disorders

Two separate studies have provided new insights into cutaneous manifestations of common endocrine disorders that, if they are present, should prompt clinicians to explore patients for underlying metabolic abnormalities that could be a harbinger for future serious complications.
In the first study, US investigators under lead author Timothy Schmidt, MD, PhD, from the University of California, San Francisco, discovered that hirsutism and the skin pigmentation disorder acanthosis nigricans, especially if located in the axillae, are the most reliable cutaneous markers of the polycystic ovary syndrome (PCOS) in women; when present, such findings should trigger further diagnostic evaluation for metabolic comorbidities that can lead to long-term complications in PCOS.
In the second study, Mohit Nagpal, MD, from the Postgraduate Institute of Medical Education and Research, Chandigarh, India, and colleagues found that postadolescent males with acne are more likely to have insulin resistance and that they, too, should be followed up for a period of time in order to detect any conditions that might develop because of the current state of insulin resistance.
Both studies were published online December 23 in JAMA Dermatology.

JAMA Dermatol. Published online December 23, 2015. Schmidt abstract, Nagpal abstract, Editorial

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