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Thigh Muscle Fat Predicts Risk of Developing Heart Failure
Sue Hughes
A higher level of intramuscular fat infiltration in the thighs was associated with a higher risk of developing heart failure, in a new study. The association was independent of other cardiometabolic risk factors and measures of adiposity such as body mass index.
The observation raises the possibility of new avenues of research aimed at modifying intramuscular fat levels as a strategy to reduce the risk of developing heart failure.
The study is published online in the July issue of JACC: Heart Failure.
The fat deposition around and within nonadipose tissues (termed “ectopic fat”), such as skeletal muscle, is also a known risk factor for cardiovascular disease, independent of adiposity. However, the impact of peripheral skeletal muscle fat deposition on heart failure risk is not as well studied.
The study results suggest that the quality of intramuscular adipose tissue might also play an important role and could be targeted by therapeutic strategies, he comments.
Carbone concludes that: “Studies testing novel modalities of exercise training, intentional weight loss, diet quality improvements with and without weight loss (ie, increase of dietary monounsaturated fatty acids, such as oleic acid), as well as pharmacological anti-inflammatory strategies should be encouraged in this population to test whether the reduction in intramuscular adipose tissue or improvements of its quality can ultimately reduce the risk for heart failure in this population.”
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