Modifying 12 risk factors over the life course could delay or prevent 40% of dementia cases, a new report suggests.

The report is an update of the Lancet Commission on Dementia Prevention, Intervention, and Care.

The original report, published in 2017, identified nine modifiable risk factors that were estimated to be responsible for one third of dementia cases. The commission has now added three new modifiable risk factors to the list.

“We reconvened the 2017 Lancet Commission on Dementia Prevention, Intervention, and Care to identify the evidence for advances likely to have the greatest impact since our 2017 paper,” the authors write.

The 2020 report was presented at the Alzheimer’s Association International Conference (AAIC) 2020, which was held online this year because of the COVID-19 pandemic. It was also published online July 30 in The Lancet.