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Weight Loss Benefit in Diabetes Is Similar via Surgery or Diet

The metabolic benefits achieved with weight loss for patients with type 2 diabetes appear to be similar whether achieved via diet or gastric bypass surgery, according to new research.

The findings, from a small study of 22 people with type 2 diabetes and obesity, were published online August 19 in The New England Journal of Medicine (NEJM). The study was conducted by Mihoko Yoshino, MD, PhD, of Washington University School of Medicine, St. Louis, and colleagues.

Among 11 patients in each group who experienced comparable degrees of weight loss (~18%), there were very similar benefits in multiorgan insulin sensitivity, beta-cell function, 24-hour plasma glucose and insulin profiles, and body composition.

“The results from our study underscore the profound effect that marked weight loss can have on metabolic function in people with diabetes,” Yoshino and colleagues write.

In addition, he noted that the relatively long average duration of diabetes in the study participants makes the success of bariatric surgery less likely.

Hutter noted, “I thought the study was very interesting. It just amazes me that 60 years after the gastric bypass procedure was invented, we’re still trying to figure out how it works.”

Hutter is a consultant for Vicarious Surgical and has received honoraria from Ethicon, Medtronic, and Olympus.

N Engl J Med. Published online August 19, 2020. Abstract, Editorial

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