Higher Weight Loss on Tirzepatide Links to Seven Factors

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Higher Weight Loss on Tirzepatide Links to Seven Factors

Among the 3188 people with type 2 diabetes who were adherent to their tirzepatide (Mounjaro, Lilly) regimen in four pivotal trials of the agent, a quarter achieved at least a 15% cut from their baseline body weight after 40–42 weeks of treatment, and researchers found seven baseline variables that were significantly linked with a higher incidence of this level of weight loss.

“These findings help inform which people with type 2 diabetes are most likely to achieve greater body weight reduction with improved cardiometabolic risk factors with tirzepatide,” say the authors.

  • The primary efficacy measure in all four studies was the ability of tirzepatide to improve glycemic control (measured by A1c level) compared with placebo, semaglutide (Ozempic) 1 mg SC once weekly, insulin degludec (Tresiba, Novo Nordisk), or insulin glargine (Basaglar, Lilly).

  • Multivariate analysis of baseline covariates showed that these seven factors were significantly linked with ≥15% weight loss: higher tirzepatide dose, being female, being of White or Asian race, being of younger age, undergoing treatment with metformin, having better glycemic control (based on lower A1c and lower fasting serum glucose), and having lower non-high-density lipoprotein cholesterol level.

Higher Weight Loss on Tirzepatide Links to Seven Factors – Medscape – Oct 26, 2023.

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