Doctors Sound Alarm on GLP-1 Weight-Loss Drugs and Death Risk

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Doctors Sound Alarm on GLP-1 Weight-Loss Drugs and Death Risk

One of the most popular new drug classes in America—GLP-1 medications such as Ozempic, Wegovy, and Zepbound—has helped a reported 12 percent of Americans lose weight or manage their type 2 diabetes. However, the benefits of these game-changing medications don’t stop there.

Besides aiding in fat loss and stabilizing blood sugar, they can also improve heart, kidney, liver, and brain health, enhance sleep, and reduce inflammation and chronic joint pain. Taken together, these advantages can amount to a longer lifespan.

However, GLP-1s also come with certain risks. The most common side effects are gastrointestinal: Some patients report experiencing nausea, vomiting, diarrhea, and constipation. According to Harvard Health Publishing, there are also a handful of “less common but more serious side effects” associated with the use of GLP-1 agonists. These include pancreatitis, gastroparesis, bowel obstruction, and gallstone problems.

Any time a person suddenly loses weight, they are also at risk of losing lean muscle mass. Not only can this affect strength, mobility, and balance, but it can also affect the immune system, metabolism, and more.

Since GLP-1 drugs can trigger rapid weight loss, many people taking them report muscle loss and reduced muscle function. In fact, between 40 and 50 percent of the total weight loss associated with GLP-1 drugs may be the result of muscle loss.

“This is a serious concern. Muscle, especially axial muscle, is essential for posture, physical function, and overall well-being,” Liu continued. “Losing lean body mass can increase the risk of cardiovascular disease, all-cause mortality and diminished quality of life. We need to make sure that patients prescribed these medications aren’t already at risk for malnutrition or low muscle mass.”

To prevent muscle loss and its effects, experts say it’s important to incorporate strength-building exercises into your GLP-1 plan. Whether you opt for dumbbells, kettlebells, gym machines, or resistance bands, you should aim to target all of your various muscle groups at least two times per week.

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