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Cannabis Compounds Show Promise for Chronic Pain Relief Without High
Yale researchers found that cannabis-derived compounds CBD, CBG and CBN reduce pain signaling by inhibiting the Nav1.8 protein in sensory neurons. CBG showed the strongest effect. The findings suggest these cannabinoids could provide safer pain relief without addiction risks, offering a promising alternative to opioids for chronic pain management.
Key Takeaways
Chronic pain is a global health challenge, with current treatment options often limited by side effects, addiction risk, and diminished effectiveness over time. In a new study, Yale researchers identify alternative compounds with therapeutic potential — chemicals found in cannabis that lack the mind-altering effects associated with the drug.
The chemicals — cannabidiol (CBD), cannabigerol (CBG), and cannabinol (CBN), which belong to a group of molecules known as cannabinoids — reduced the activity of a protein that is central to pain signaling in the peripheral nervous system, the study showed.
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