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Cholesterol Drugs and Muscle Weakness is Real
I am sure thaqt you have been through this: you inform your doctor that the anti-cholesterol drug you are using causes you muscle pain. The doctor tells you that it is in your head and that there is no link between the drug you were prescribed and your pain in your legs climbing stairs (the usual scenario). Maybe the doctor prescribes you CoQ-10 which does seem to help but you now believe that your doctor thinks you are faking the pain and, perhaps, you feel ashamed.
It looks like the doctor was wrong you were were right all along. We now know the mechanism of this problem and why it is happening to you.
But why should an anticholesterol drug (specifically, stains) weaken muscles in the arms and legs? Recently, two groups of scientists stumbled upon an answer. They didn’t set out to study statins. They weren’t studying cholesterol at all. They were hunting for genes behind a rare disease called limb girdle muscle dystrophy, in which muscles of the upper arms and legs—sound familiar?—become weak and waste away. After both teams tracked the disease through a handful of families in the U.S.and a Bedouin family in Israel, their suspicions separately landed on mutations in a gene encoding a particularly intriguing enzyme.
The enzyme is known as HMG-CoA reductase, and to doctors, it is not obscure. It is, in fact, the very enzyme that statins block in the process of halting cholesterol production. And so, the answers to two mysteries suddenly became clear at once: Dysfunction in this enzyme causes muscle weakness from both limb girdle muscular dystrophy and statins.
This connection between a rare disease and a common drug stunned the researchers. “It seemed too good to be true,” says Joel Morales-Rosado, a pathologist who worked on one of the studies as a postdoctoral researcher at the Mayo Clinic. “One of the first things you learn in medical school is association between statins and myopathy.” Now the answer as to why— along with a potential treatment for it—has emerged from the DNA of just a few patients living with a seemingly unrelated genetic disease.
via Blogger https://bit.ly/3NTluOk
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