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Cychlorphine, the synthetic opioid 10 times stronger than fentanyl
Multiple states have issued warnings in the past month about cychlorphine, a synthetic opioid linked to dozens of recent overdoses and estimated to be far more potent than fentanyl.
Cychlorphine—also known as N‑propionitrile chlorphine—is part of a new wave of synthetic opioids entering the U.S. illicit drug supply. It has never been approved for human use. Like fentanyl, it is often mixed into other street drugs, but unlike fentanyl, it is not detectable with standard fentanyl test strips, increasing its danger. Naloxone (Narcan) is still believed to be effective in reversing overdoses caused by this drug.
The DEA first identified the substance in Florida in April 2024 and has detected it in at least 22 samples through February 2026. Public health alerts have since emerged across multiple states. In East Tennessee, cychlorphine has been linked to 19 overdose deaths, while officials in Ohio and Kentucky have recently issued warnings.
According to the Center for Forensic Science Research & Education, cychlorphine may be about 10 times more potent than fentanyl. Given that fentanyl itself is 50–100 times stronger than heroin, even extremely small amounts of cychlorphine can be lethal. Its presence in fatal overdoses has been increasing since mid-2025, with detections reported in states including New York, Pennsylvania, Texas, and California.
Experts say users are often unaware they are taking cychlorphine, as it is mixed into other drugs. Its extreme potency also makes it attractive within addiction cycles, where individuals may seek stronger substances to achieve the same effect. Specialists emphasize that addiction is a brain disorder that alters decision-making, not simply a matter of choice.
Researchers and officials warn that cychlorphine is part of a broader and continuing wave of synthetic opioids. It is unlikely to replace fentanyl, but rather to coexist with it, further complicating overdose prevention and detection efforts.
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