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Early Parkinson’s Symptoms Decrease Linked to Healthy Diets

Adherence to dietary patterns that emphasize vegetables, fruits, nuts, and grains, such as in the Mediterranean diet, is inversely associated with prodromal features of Parkinson’s disease (PD), including constipation, excessive daytime sleepiness, and symptoms of depression, new research suggests.

These results, from a cohort study of more than 47,000 participants, are consistent with findings from previous research, the investigators note.

Although the current study suggests that adherence to a healthy diet may reduce occurrence of nonmotor symptoms that precede the diagnosis of PD, prospective research is now needed to determine whether adherence can delay or prevent the onset of the disease itself in patients with prodromal symptoms, they add.

A growing body of evidence suggests that the gut and enteric nervous system may be involved in the pathogenesis of PD, noted lead author Samantha A. Molsberry, PhD, a postdoctoral research fellow at Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Samantha Molsberry, PhD

Following a healthy dietary pattern may influence risk for PD or prodromal PD features “by protecting against α-synuclein aggregation in the gut or by otherwise promoting gut health in a manner protective against degeneration in the enteric nervous system or CNS,” she told Medscape Medical News.

Healthy diets include foods that are high in antioxidant and anti-inflammatory compounds. Therefore, diet pattern may “reduce risk of Parkinson’s disease or prodromal Parkinson’s disease features by preventing oxidative stress and neuroinflammation,” Molsberry added.

The findings were published online August 19 in Neurology.

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