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Adding as little as 9 pounds of extra fat, specifically in the abdomen, increases the risk of developing endothelial cell dysfunction. Endothelial cells line the blood vessels and control the ability of the vessels to expand and contract. For those who gained weight in their abdomens, even though their blood pressure was normal, their regulation of blood flow through their arm arteries was impaired due to endothelial dysfunction. Once they lost the weight, the blood flow recovered. Blood flow regulation was unchanged in the people who maintained their weight and was less affected among those who gained weight evenly throughout their bodies. Journal of the American College of Cardiology, August 2010
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