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Exercise Training Reduces Liver Fat in Patients With NAFLD, Even Without Weight Loss
Exercise training is 3.5 times more likely to result in a clinically meaningful response in liver fat, compared with standard clinical care, for patients with nonalcoholic fatty liver disease (NAFLD), according to a new systematic review and meta-analysis.
An exercise dose of 750 metabolic equivalents of task (MET)-minutes/week — or 150 minutes per week of brisk walking — was required to achieve a treatment response, independently of weight loss.
“In the absence of a regulatory agency-approved drug treatment or a cure, lifestyle modification with dietary change and increased exercise is recommended for all patients with NAFLD,” first author Jonathan Stine, MD, an associate professor of medicine and public health sciences and director of the Fatty Liver Program at the Penn State Health Milton S. Hershey Medical Center, in Hershey, Pennsylvania, told Medscape Medical News.
“With that said, there are many key unanswered questions about how to best prescribe exercise as medicine to our patients with NAFLD, including whether the liver-specific benefit of exercise can be seen without any body weight loss,” Stine said. “And if found, what dose of exercise is required in order to achieve clinically meaningful benefit?” He noted that this analysis is a step toward helping to answer these questions.
The study by Stine and his colleagues was published online in The American Journal of Gastroenterology.
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