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Inhaled Cannabis Is “Safe and Effective” for Treating Refractory Diabetic Neuropathy
Cannabis use is associated with sustained reductions in analgesia and improvements in glycemic control in patients suffering from diabetic neuropathy, according to longitudinal data published in the journal Biomedicines.
Israeli researchers assessed the adjunctive use of inhaled cannabis in a cohort of 50 patients suffering from treatment-resistant diabetic neuropathy. Study participants inhaled standardized, medical-grade cannabis flower (20 percent THC | 1 percent CBD) for five years.
Patients reported significant decreases in their pain scores, as well reductions in their use of opioids and other prescription analgesics, over the span of the study. Specifically, participants decreased their morphine-equivalent doses by more than 90 percent, their gabapentin doses by 97 percent, duloxetine by 93 percent, and pregabalin by 79 percent without developing rebound pain. Patients’ pain severity decreased from a mean of nine to two on a numerical rating scale.
Study participants also exhibited improvements in their A1c scores (glucose levels) following their sustained use of cannabis — a finding that is consistent with other studies assessing the impact of cannabinoids on glycemic control.
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