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Marijuana Use Tied to Heart Failure, MI, Stroke
Daily marijuana use was associated with a 34% increased risk for heart failure within 4 years compared with nonuse, in new observational research.
In a separate study, cannabis use disorder (CUD) was linked with a 20% increased risk for major adverse cardiac and cerebral events (MACCEs) during hospitalization in older patients with cardiovascular risk who were tobacco nonsmokers.
The studies will be presented on November 13 at the upcoming American Heart Association (AHA) 2023 Scientific Sessions.
Marijuana Use and Risk for Heart Failure
Marijuana use in the United States has increased exponentially with increasing state-level legalization, but its effect on cardiovascular health is unclear, Yakubu Bene-Alhasan, MD, MPH, and colleagues write.
They identified 156,999 adults aged 18 years or older who did not have a diagnosis of heart failure at baseline. Participants had a mean age of 54 years, and 61% were women.
About one quarter had hypertension (24%) or hyperlipidemia (23%), 9.2% had type 2 diabetes, and 9% had coronary artery disease (CAD). They had a median body mass index (BMI) of 28; 17% were current smokers, and 22% were former smokers. Almost all had insurance (95%).
On the basis of the participants’ reported marijuana use, defined as unprescribed use or use beyond prescribed doses over the previous 3 months, they were classified as never-users (107,976 participants); former users (33,816); or less than monthly (7292), monthly (1686), weekly (2326) or daily (3903) users.
About one third of the patients with CUD in this study also had drug abuse. Page observed, which “kind of muddies the water a little,” because drugs such as cocaine and methamphetamine can lead to increased risk for atherosclerotic cardiovascular disease (ASCVD).
Nevertheless, both studies add to “the overwhelming evidence that has been generated over the last 5 years that maybe cannabis is going to be a potential risk factor for ASCVD disease or contributing to it,” Mondal said.
https://www.medscape.com/viewarticle/998288
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