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Newer Anti-obesity Meds Lower the Body’s Defended Fat Mass
The current highly effective antiobesity medications approved for treating obesity (semaglutide), under review (tirzepatide), or in late-stage clinical trials “appear to lower the body’s target and defended fat mass [set point]” but do not permanently fix it at a lower point, Lee M. Kaplan, MD, PhD, explained in a lecture on October 15 at ObesityWeek.
It is very likely that patients with obesity will have to take these anti-obesity medications “forever,” he said, “until we identify and can repair the cellular and molecular mechanisms that the body uses to regulate body fat mass throughout the life cycle and that are dysfunctional in obesity.”
“The body is able to regulate fat mass at multiple stages during development,” Kaplan, from Massachusetts General Hospital and Harvard Medical School, Boston, explained, “and when it doesn’t do it appropriately, that becomes the physiological basis of obesity.”
The loss of baby fat, as well as fat changes during puberty, menopause, aging, and, in particular, during and after pregnancy “all occur without conscious or purposeful input,” he noted.
Newer Antiobesity Meds Lower the Body’s Defended Fat Mass – Medscape – Nov 07, 2023.
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