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Opioids for Back, Neck Pain No Better Than Placebo
Opioids do not relieve acute low back or neck pain in the short term and lead to worse outcomes in the long term, results of the first randomized controlled trial testing the efficacy and safety of a short course of opioids for acute nonspecific low back/neck pain suggest.
After 6 weeks, there was no significant difference in pain scores of patients who took opioids compared to those who took placebo. After 1 year, patients given the placebo had slightly lower pain scores. Also, patients using opioids were at greater risk of opioid misuse after 1 year.
This is a “landmark” trial with “practice-changing” results, senior author Christine Lin, PhD, with the University of Sydney, told Medscape Medical News.
“Before this trial, we did not have good evidence on whether opioids were effective for acute low back pain or neck pain, yet opioids were one of the most commonly used medicines for these conditions,” Lin explained.
On the basis of these results, “opioids should not be recommended at all for acute low back pain and neck pain,” Lin said.
Results of the OPAL study were published online June 28 in The Lancet.
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