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Shingles Vaccine Appears to Lower Dementia Risk
- Studies suggest shingles vaccines, Zostavax and Shingrix, may reduce dementia risk in older adults.
- An Australian study found that elderly adults eligible for free doses of Zostavax were less likely to get a dementia diagnosis.
- Shingrix might have a stronger protective effect than Zostavax, per a U.S. study in Nature Medicine.
Mounting evidence suggests that vaccination against the varicella zoster virus—which causes chickenpox in children and triggers shingles in adults—also protects the brain.
Several recent studies suggest that the vaccines reduce the risk of dementia in older adults, but key questions remain, including: How the vaccines might work to stop or delay the condition, and whether the benefit is limited to people of a certain age.
The vaccines studied, Zostavax and Shingrix, both appeared to offer protection.
The latest study found that among 70- and 80-year-olds in Australia, people who were eligible to get the Zostavax shot were 1.8 percentage points less likely to get a dementia diagnosis in the next 7.4 years than those who were ineligible. The study was published in the journal JAMA Wednesday.
The Stanford University team that did the work zoomed in on a government initiative—launched in Australia starting Nov. 1, 2016—that offered the shingles vaccine Zostavax free to people between 70 and 79 years old. People who were born after Nov. 1, 1936, were able to get the free shot, but people born on or before that date weren’t.
“All that’s different between them is whether they were born a few days earlier or a few days later,” said Pascal Geldsetzer, a Stanford University epidemiologist and an author of the study.
The study included 18,400 people in their 70s and 80s when the program launched. The effectiveness of Zostavax for preventing shingles drops after the age of 80.
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