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Single Injection Reduces Blood Pressure for 6 Months: KARDIA-1
A single injection of the investigational antihypertensive agent zilebesiran (Alnylam Pharmaceuticals) effectively lowered blood pressure in adults with mild to moderate hypertension for up to 6 months, with what appeared to be an encouraging side-effect profile, in the phase 2 dose-ranging KARDIA-1 study.
“Our study demonstrates that either quarterly or bi-annual doses of zilebesiran can effectively and safely lower blood pressure in patients with uncontrolled hypertension,” said senior study investigator, George Bakris, MD.
“Based on these results, zilebesiran has the potential to improve medication adherence, which will, in turn, reduce cardiovascular risk in people with hypertension,” Bakris, who is professor of medicine and director of the Comprehensive Hypertension Center at the University of Chicago Medicine, added.
The KARDIA-1 study was presented on November 11 at the recent American Heart Association (AHA) Scientific Sessions 2023, held in Philadelphia.
via Blogger https://bit.ly/46qlPxW
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