Vegan Diet Confers Cardiometabolic Benefits

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Vegan Diet Confers Cardiometabolic Benefits

Compared with a healthy omnivore diet, a healthy vegan diet led to significant improvement in low-density lipoprotein cholesterol (LDL-C) as well as fasting insulin and weight loss in a randomized controlled trial of identical twins. 

METHODOLOGY:  

  • Researchers randomly assigned 22 pairs of healthy adult identical twins (34 women, mean age 39 years, mean body mass index 25.9) to a healthy vegan or omnivore diet (1 twin per pair) for 8 weeks.
  • For the first 4 weeks, diet-specific meals were provided via a meal delivery service. For the final 4 weeks, participants prepared their own diet-appropriate meals/snacks.
  • The primary outcome was change in LDL-C; secondary outcomes included changes in body weight and fasting insulin. 

TAKEAWAY:

  • After 8 weeks, twins eating a vegan diet showed a significant mean decrease of 13.9 mg/dL in LDL-C compared with twins eating an omnivorous diet.
  • The vegan diet also led to a significant mean decrease of 2.9 μIU/mL in fasting insulin and 1.9 kg in body weight after 8 weeks compared with the omnivore diet, although weight loss was observed in both diet groups. 
  • The vegan diet group also had a larger but nonsignificant absolute median decrease in fasting HDL-C, triglycerides, vitamin B12, glucose, and trimethylamine N-oxide levels at 8 weeks.

SOURCE: 

The study, with first author Matthew J. Landry, PhD, RDN, Stanford Prevention Research Center, Stanford University School of Medicine, California, was published online November 30 in JAMA Network Open. 

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