You might wonder if THC have a negative impact on physiology or anatomy

THC elevates heart rate by 20-50 beats per minute, increasing cardiac workload and raising heart attack risk, especially in those with heart disease. It irritates the respiratory tract, leading to chronic cough, bronchitis, and higher lung infection risk when smoked. THC may suppress the immune system, potentially increasing susceptibility to infections, though effects vary.

Chronic THC exposure links to reduced gray matter volume in brain regions like the hippocampus, orbitofrontal cortex, and precuneus, impairing memory and cognition. These structural alterations, including thinner cortical areas and disrupted connectivity, appear more pronounced with adolescent use or long-term exposure. Animal studies show THC blocks neurogenesis and causes neuronal damage in high CB1 receptor areas.

Risks intensify with high THC potency, frequent use, or vulnerable groups like adolescents and pregnant individuals. While some benefits exist for pain or nausea, negative effects often outweigh them in non-medical contexts.