Antidepressants in Pregnancy Linked to Increased Autism Risk

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Antidepressants in Pregnancy Linked to Increased Autism Risk

UPDATED December 15, 2015 // Antidepressant use during the second or third trimester of pregnancy, particularly use of selective serotonin reuptake inhibitors (SSRIs), nearly doubles the risk of the child’s developing autism spectrum disorder (ASD) by age 7 years, new research shows.

The study also showed that maternal history of depression is associated with an increased risk for ASD, albeit the risk is smaller.
“In our multivariate analysis, we found that treatment of depression with antidepressants in the second and/or third trimester of pregnancy was independently associated with an 87% increase risk of having a child with autistic spectrum disorder,” Anick Bérard, PhD, of the University of Montreal’s Faculty of Pharmacy, in Montreal, Canada, told Medscape Medical News.
“We further found that a history of maternal depression was an independent risk factor for having a child with ASD, increasing the risk by 20%.”
The study was published online December 14 in JAMA Pediatrics.

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