Between Pregnancy Weight Gain Increases Risk for Infant Death

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Interpregnancy Weight Gain Increases Risk for Infant Death



Maternal weight gain between pregnancies increases the risk for stillbirth and infant death during the first year of life, according to a nationwide cohort study published online December 2 in the Lancet.
“Our findings might potentially have substantial public health implications,” write Sven Cnattingius, MD, from the Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, and Eduardo Villamor, MD, from the Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor.
“15% of the women gained 2 to less than 4 [body mass index (BMI)] units between pregnancies (corresponding to 6–11 kg in women of average height), and 6% gained at least 4 BMI units. Such weight gains would increase stillbirth risks by 30–50%, irrespective of weight in first pregnancy. The same weight gains would increase risks of infant mortality by 27% and 60%, respectively, in offspring of women with a healthy weight in first pregnancy. Conversely, in overweight women, we found that a weight reduction of more than 2 BMI units (corresponding to at least 6 kg) was related to about a 50% lower risk of neonatal mortality,” they report.
Overweight and obesity are growing problems worldwide, and because they are associated with pregnancy complications, they may have implications for infant health. Maternal weight gain between consecutive pregnancies is linked to complications such as preeclampsia, gestational diabetes, and preterm birth or stillbirth. This association is more pronounced in women with a healthy weight at first pregnancy than in those who are overweight or obese.
Lancet. Published online December 2, 2015. Article abstract, Comment extract

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