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Cluster, Migraine Headache Strongly Linked to Circadian Rhythm
Cluster headache and migraine have strong ties to the circadian system at multiple levels, new findings that could have significant treatment implications.
A meta-analysis of 16 studies showed a circadian pattern in 71% of cluster headache attacks (3490 of 4953), with a clear circadian peak between 9:00 PM and 3:00 AM.
Migraine was also associated with a circadian pattern in 50% of cases (2698 of 5385) across eight studies, with a clear circadian trough between 11:00 PM and 7:00 AM.
Seasonal peaks were also evident for cluster headache (spring and autumn) and migraine (April to October).
“In the short-term, these findings help us explain the timing to patients — for example it is possible that a headache at 8 AM is due to their internal body clock instead of their pillow, or breakfast food, or morning medications,” lead investigator Mark Burish, MD, PhD, associate professor, Department of Neurosurgery, McGovern Medical School at UTHealth Houston, told Medscape Medical News.
“In the long-term, these findings do suggest that medications that target the circadian system could be effective in migraine and headache patients,” Burish added.
The study was published online March 29 in Neurology.
Neurology. Published online March 29, 2023. Article; Editorial
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